Polymorphism of inflammatory system genes in the pathogenesis of rheumatic heart disease

Aim . To assess the contribution of polymorphic variants inflammatory response genes to predisposition rheumatic heart disease. Material and methods Using real-time polymerase chain reaction, we analyzed prevalence 18 8 involved in process 251 patients with disease 300 healthy donors. Results We found that homozygous TT genotypes rs1800871 (IL10) (p=0,02) rs1800872 polymorphisms (p=0,027), as well CRP gene (rs1205) (p=0,015) GG rs375947 (IL12RB) (p=0,037) are "risky" associated development Conclusion Associations IL10 gene, rs1205 IL12RB can be an important link pathogenesis later used biological markers for a personalized assessment risk.